I spent most of the evening cleaning out old, screwed up USB drivers on my notebook. Note that this is a lot harder than it sounds, since the Device Manager by default does not show the drivers for USB devices that are not presently detected as being plugged in. And if your driver is screwed up, the machine often does not detect it being plugged in...
There is a way to show all devices, though, even "ghosted" ones: http://support.microsoft.com/kb/315539/en-us
I killed a slew of badly installed USB devices, removed C-Dilla (an obnoxious copy-protection program that other programs often install behind your back), and cleaned out the last of that crap Norton anti-virus.
Oh my god, does my notebook FLY now! I have a 7 or 8 source file project that used to take 15-20 seconds to recompile from scratch. It takes 3 seconds now. It takes me longer to plug the programmer into the target board than it does to recompile the entire project from clean. Score!
Oh yeah, if you don't have anti-virus software installed, and want to get rid of that obnoxious as @#$% "Microsoft's profits^W^WYour computer might be AT RISK!" balloon that keeps popping up in the lower right?
Yeah baby! Yeah!!